WHSC2 Antibody (Center) Catalog Number：OM224700

Antibody TypePrimary Antibodies

Key Feature

ClonalityPolyclonal

Product Profile

Product NameWHSC2 Antibody (Center)IsotypeIgHost SpeciesRabbitTested ApplicationsWB

WB~~1:100~500:

Species ReactivityHuman

Concentration1 mg/mlPurification

Target Information

Gene SynonymsWHSC2

Alternative NamesWHSC2

NELFA

Negative elongation factor A

Wolf-Hirschhorn syndrome candidate 2 protein

More Molecular Weight(MW)57277 DaFunctionEssential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex ａnd causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex

More Tissue SpecificityUbiquitous. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney ａnd pancreas. Expressed at lower level in adult lung. Expressed in fetal brain, lung, liver ａnd kidneyCellular LocalizationNucleus.

Database Links

Entrez Gene7469Nucleotide AccessionNP_005654.3

Application

ApplicationWHSC2 Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the WHSC2 antibody detected the WHSC2 protein (arrow).

Application NotesWB~~1:100~500:

Additional Information

FormLiquidStorage InstructionsFor short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.Storage BufferPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.